The Series 343 Numatics Air Isolation Valves are manual valves that are used to shut off the downstream air flow in machinery and systems. They feature a lockable handle that can be padlocked to prevent pressurization of the system after the manual shutoff. This provides an additional level of safety and security, and helps prevent accidental or unauthorized activation of the machinery. These valves are typically used in industrial and manufacturing settings to isolate specific sections of a pneumatic system for maintenance or repairs.